Main Media English

Get Latest News, India News, World News at Main Media English

Support Us

Researchers develop potential new drug treatment for multiple sclerosis

IANS logo Reported By IANS |
Published On :

Toronto, Dec 9 (IANS) A small molecule drug that aids in the neuro-protection of cells has been found to be effective in treating nerve damage and symptoms in models of multiple sclerosis (MS).

MS is a progressive neurological disease that currently has no cure.

Also Read Story

Empty chairs, forced attendance allegations cast shadow on INDIA bloc’s Delhi rally

Nagaland’s sole LS seat to witness triangular contest in 2024 polls

Odisha Crime Branch busts racket involved in Rs 1.04 cr fraud

IPL 2024: Under-pressure Mumbai Indians hope to shine in home comfort (Preview)

IPL 2024: Sai Sudharsan, David Miller star as clinical Gujarat beat Hyderabad by seven wickets

Viksit Bharat Ambassador meet-up: India is world’s 3rd largest start-up ecosystem today, says I&B Minister Anurag Thakur

Amit Shah chairs meeting of Lok Sabha core committees in Jaipur, holds roadshow in Sikar

IPL 2024: Ishant Sharma back as Delhi Capitals win toss, elect to bat against CSK

Viksit Bharat Ambassador Jaipur meet-up: Participants heap praise on the initiative

It is associated with a wide-range of debilitating symptoms, including problems with coordination, cognition, muscle weakness and depression.


For unknown reasons, it is more common in northern latitudes and more than twice as common in women.

It is known that MS damages myelin, a protective sheath that forms around nerves in the brain and spinal cord.

As the myelin damage is triggered by inflammation in the immune system, up until now all current drug treatments for MS target the immune system.

The study, published in the journal Science Advances, showed that the newly synthesised lead compound not only reduced MS-like symptoms, it also may repair the damaged myelin in two different pre-clinical models of MS.

“Our compound had a stunning effect on rescuing myelin and motor function in the lab models, and I hope these effects will translate to the clinic to add to current treatments and bring new hope to patients with MS,” said Dr. Fang Liu Senior Scientist at Centre for Addiction and Mental Health (CAMH) in Canada.

“As with cancer chemotherapy drug cocktails, simultaneous targeting of the MS disease pathway at multiple points can have synergistic effects and result in better outcomes,” Liu added.

In this study, CAMH and her team treated MS in a completely different way — targeting the glutamate system. Liu believes that the evidence of efficacy and tolerability generated in this study for the small molecule drug makes it a good candidate to be developed for human trials.

Iain Greig, Reader in Medicinal Chemistry at the University of Aberdeen, is working alongside to turn the molecules identified by Liu into advanced “drug-like” molecules suitable for continued development towards clinical use in patients.

“In all my years as a medicinal chemist, I have never seen a more promising starting point for a drug development project. It has been a huge pleasure to be involved in this programme and I am looking forward to continuing to drive it towards the clinic,” he added.

–IANS

rvt/pgh

(This report is auto-generated from IANS news service. 'Main Media' holds no responsibility for its content.)

Get involved in bringing the ground realities of Seemanchal. Click the "Support Us" button to join our membership.

Support Us

Related News

Pawar vs Pawar: A fight for supremacy in Baramati

Rebel Wilson opens up on weight loss journey, says she’s an emotional eater

Shraddha Kapoor asks fans how they wasted 1st quarter of 2024

PM Modi virtually interacts with party workers in Varanasi

AIADMK will ally again with BJP after LS elections, says Chidambaram

PE-VC investments fall by 8 per cent to $6.2 billion in Q1

Cut! Mark Ronson’s role in Amy Winehouse biopic gets axed

Leave a Reply

Your email address will not be published. Required fields are marked *